Is it true that scientists have achieved successful results on controlling human aging? If you are interested to know the answer, just grab a cup of tea and go on reading.
The key is GENE THERAPY. Scientists spent a long time working on this issue, it took them loads of effort to reach the goal.
“Wouldn’t it be better for society if people could be healthy and productive for a longer period during their lifetime?” Morimoto said in the statement.
Scientists firstly started working on nonhumans, until they claimed that all Genetic modifications in other species have not achieved as great a lifespan extension as have been seen forC. elegans. Drosophila melanogasterlifespan has been doubled. And that was the first successfully achievement on nonhumans.
Afterwards, they started working on humans. Researchers in Japan have found that human aging may be able to be delayed or even reversed, at least at the most basic level of human cell lines. In the process, the scientists from the University of Tsukuba also found that regulation of two genes is related to how we age. And finally most intriguing, the team led by Professor Jun-Ichi Hayashi was able to flip the switches on a few genes back to their youthful position, effectively reversing the aging process.
The researchers came to this conclusion by comparing the function level of the mitochondria in fibroblast cell lines from children under 12 years of age to those of elderly people between 80 and 97. As expected, the older cells had reduced cellular respiration, but the older cells did not show more DNA damage than those from children. This discovery led the team to propose that the reduced cellular function is tied to epigenetic regulation, changes that alter the physical structure of DNA without affecting the DNA sequence itself, causing genes to be turned on or off.
To test the theory, the researchers found two genes associated with mitochondrial function and essentially experimented with turning them on or off. In doing so, they were able to create defects or restore cellular respiration. These two genes regulate glycine, an amino acid, production in mitochondria, and in one of the more promising findings, a 97-year-old cell line saw its cellular respiration restored after the addition of glycine for 10 days.
The researches’ findings were published on May 27th, 2015 the journal Scientific Reports.
Recently, The CEO of Bioviva USA Inc, Elizabeth Parrish, claims to be the first human in world history to have successfully reversed the effects of natural ageing – thanks to experimental gene therapy provided by her company.
Originally meant to prove that her company’s gene therapy was safe, the results – should they prove to be effective in the long-term and withstand due scientific scrutiny – would be the very first successful demonstration of telomere lengthening in any human.
“Current therapeutics offer only marginal benefits for people suffering from diseases of ageing. Additionally, lifestyle modification has limited impact for treating these diseases. Advances in biotechnology is the best solution, and if these results are anywhere near accurate, we’ve made history,” Parrish notes.
To that end, even Parrish is clear tha investigation is necessary in order to verify the methods; however, if verified, this work will be revolutionary.
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